In addition to its endogenous occurrence, L-threonine acid can be found in a wide variety of foods, such as canned mushrooms, fruit juice and processed meats (AZZAM et al., 2011), as the major part of Vitamin C metabolites. In humans, L-threonine acid is an ascorbic acid metabolite (FAY VERLANGIERI, 1991), having been identified in plasma (DEUTSCH et al., 1999), in the aqueous humor (HARDING et al., 1999), in the urine (THOMPSON et al., 1975 LAWSON et al., 1976) and in the brain (Sun et al., 2016). In addition, it was able to significantly elevate magnesium concentrations (7% to 15% of initial value in 24 days) in cerebrospinal fluid in rats when administered orally, while other magnesium compounds could not. According to the study, magnesium-L-threonate (Magtein®) is a superior magnesium source to other magnesium compounds because it has a higher bioavailability when compared to other sources of magnesium, such as chloride, citrate, glycinate and gluconate, demonstrated by higher absorption and higher retention. In a Neuron publication of 2010, scientists from the Massachusetts Institute of Technology (MIT) discovered a magnesium compound called magnesium-L-threonate (Magtein®), that can effectively deliver magnesium to brain cells (SLUTSKY et al., 2010).
A61K45/00- Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00.A61K33/06- Aluminium, calcium or magnesium Compounds thereof, e.g.A61K33/00- Medicinal preparations containing inorganic active ingredients.phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. A61K31/685- Diesters of a phosphorus acid with two hydroxy compounds, e.g.A61K31/683- Diesters of a phosphorus acid with two hydroxy compounds, e.g.fosfosal, dichlorvos, malathion or mevinphos A61K31/661- Phosphorus acids or esters thereof not having P-C bonds, e.g.nitroglycerine, selenocyanates of carboxylic acids valproic acid having two or more hydroxy groups, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids A61K31/185- Acids Anhydrides, halides or salts thereof, e.g.
A61K31/00- Medicinal preparations containing organic active ingredients.
A61K- PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES.A61- MEDICAL OR VETERINARY SCIENCE HYGIENE.Assignors: GU, Jennifer, LIU, GUOSONG Publication of US20220054537A1 publication Critical patent/US20220054537A1/en Status Pending legal-status Critical Current Links Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.) Filing date Publication date Priority claimed from US202062986375P external-priority Application filed by Neuro Supplements LLC filed Critical Neuro Supplements LLC Priority to US17/194,733 priority Critical patent/US20220054537A1/en Assigned to Neuro Supplements, LLC reassignment Neuro Supplements, LLC ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Original Assignee Neuro Supplements LLC Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.) Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.) Pending Application number US17/194,733 Inventor Jennifer Gu Guosong Liu Current Assignee (The listed assignees may be inaccurate. Google Patents US20220054537A1 - Magnesium-l-threonate and neurotransmitter compositions and related methods US20220054537A1 - Magnesium-l-threonate and neurotransmitter compositions and related methods
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